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LSP Project 2-5

The Trojan horse strategy: An innovative method to control human- and phytopathogenic fungi

It is widely accepted that fungal pathogens have an enormous potential to affect plant, animal and human health. During the life time every fourth human (or ~ 1.7 billion) suffers from least one fungal infection. Of particular concern is the high rate of mortality (up to 95%) associated with invasive fungal mycosis, which often cannot be treated with several available antifungal drugs. Those antifungal drugs are not only used in human healthcare but also in agriculture. But during the last decade a decrease of efficiency of diverse antifungal compounds was observed. Further complications include the toxicity, undesirable drug interactions, and bioavailability in target tissue, thus limiting the development and release of new therapeutic agents (Brown et al., 2012). Therefore the development of an innovative strategy is essential to fight against such pathogenic fungi.