Projects
The research projects within the joint research program fall into the following categories:
1. Structure and function of membrane proteins and their integration into signaling pathways
Biological membranes form the outer barrier of each cell and, in addition, separate intracellular organelles from each other and from the cytoplasm.
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2. Proteins in transcriptional and post-transcriptional gene regulation
Gene expression is regulated dependent on cell differentiation and environmental conditions. This happens first at the level of transcription.
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3. Protein modification, signal transduction, protein interactions and proteomics
Post-translational protein modifications are important for the spatially and temporally controlled activation or inactivation of proteins or signaling events. Examples of such modifications are phosphorylation, acetylation or ubiquitination.
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4. Protein structure, folding and dynamics
Understanding the mechanisms of catalysed and non-catalysed protein folding is one of the established research interests in Halle. The „Mitteldeutsches Zentrum für Struktur und Dynamik von Proteinen“ supports this research focus: Considering conformational states and structural intermediates occuring during protein folding, protein structures are described on the atomic level.
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5. Proteins in the regulation of processes in plants
Plants can perceive their environment and respond to stress, e. g. through infection by pathogens, herbivorous insects, increased light intensities or temperatures, by molecular adaption processes. Both perception of environmental signals and their transformation into intracellular signals relies on functions of specific proteins.
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