Martin-Luther-Universität Halle-Wittenberg

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Publications

Prof. Kirsten Bacia

  • Zanetti, G., Prinz, S.,  Daum, S., Meister, A., Schekman, R., Bacia, K., Briggs, J.A.G. (2013) The structure of the COPII coat assembled on membranes, eLife 2013, 2:e00951, DOI: 10.7554/eLife.00951
  • Daum, S.,  Kruger, D., Meister, A., Auerswald, J., Prinz, S., Briggs, J.A.G., Bacia, K. (2014) Insights from reconstitution reactions of COPII vesicle formation using pure components and low mechanical perturbation, Biol. Chem. 2014, 395(7-8):801-812, DOI 10.1515/hsz-2014-0117

Prof. Sacha Baginsky

  • Helm S., Dobritzsch D., Rödiger A., Agne B., Baginsky S. Protein identification and quantification by data-independent acquisition and multi-parallel collision-induced dissociation mass spectrometry (MSE) in the chloroplast stroma proteome.    J Proteomics. 2013 Dec 18;98C:79-89. doi: 10.1016/j.jprot.2013.12.007. [Epub ahead of print] PMID:24361574 [PubMed - as supplied by publisher]
  • Grimmer, J., Rödiger, A., Hoehenwarter, W., Helm, S. and Baginsky, S. (2014). The RNA-binding protein RNP29 is an unusual Toc159 transport substrate. Frontiers in Plant Sciences 5, 258
  • Schönberg, A., Bergner, E., Helm, S., Agne, B., Dünschede, B., Schünemann, D., Schutkowski, M. and Baginsky, S. (2014). The peptide microarray “ChloroPhos1.0” identifies new phosphorylation targets of plastid casein kinase II (pCKII) in Arabidopsis thaliana. PlosOne 9, e108344
  • Herzberg, M., Dobritzsch, D., Helm, S., Baginsky, S. and Nies, D.H. (2014). The zinc repository of Cupriavidus metallidurans. Metallomics 6, 2157-65
  • Betterle, N., Ballottari, M., Baginsky, S. and Bassi, R. (2015). High light-dependent phosphorylation of Photosystem II inner antenna CP29 in monocots is STN7-independent and enhances Non Photochemical Quenching. Plant Physiology 197, 419-429

Prof. Jochen Balbach

  • Morgado, I., Wieligmann, K., Bereza, M., Rönicke, R., Meinhardt, K., Annamalai, K., Baumann, M., Wacker, J., Hortschansky, P., Malesevic, M., Parthier, C., Mawrin, C., Schiene-Fischer, C., Reymann, K.G., Stubbs, M.T., Balbach, J., Görlach, M., Horn, U.,Fändrich, M. (2012) Molecular basis of β-amyloid oligomer recognition with a conformational antibody fragment. PNAS 109: 12503-12508
  • Kumar, A., Gopalswamy, M., Wishart, C., Henze, M., Eschen-Lippold, L., Donnelly, D., Balbach, J. (2014) N–terminal Phosphorylation of Parathyroid Hormone (PTH) Abolishes its Receptor Activity. ACS Chem. Biol., 9, 2465-2470.
  • Daum, B., Auerswald, A., Gruber, T., Hause, G., Balbach, J., Kühlbrandt, W., Meister, A. Supramolecular organization of the human N-BAR domain in shaping the sarcolemma membrane. PNAS, eingereicht (2015)
  • Gruber, T., Balbach, J. Protein folding mechanism of the dimeric AmphiphysinII/Bin1 N-BAR domain. PLOS ONE, unter Revision (2015)

Prof. Sven-Erik Behrens

  • Friedrich, S., Schmidt, T., Geissler, R., Lilie, H., Chabierski, S., Ulbert, S., Liebert, U.G., Golbik, R., Behrens, S.E. (2014) AUF1 p45 Promotes West Nile Virus Replication by an RNA Chaperone Activity That Supports Cyclization of the Viral Genome. JVirol 88: 11586-11599

Prof. Ralf Anton Benndorf

  • Bauer, J., Ripperger, A., Frantz, S., Ergün, S., Schwedhelm, E., Benndorf, R.A. (2014) Pathophysiology of isoprostanes in the cardiovascular system: implications of isoprostane-mediated thromboxane A2 receptor activation. Br J Pharmacol. 2014; 171:3115-31
  • Krebs, C.F., Lange, S., Niemann, G., Rosendahl, A., Lehners, A., Meyer-Schwesinger, C., Stahl, R.A., Benndorf, R.A., Velden, J., Paust, H.J., Panzer, U., Ehmke, H., Wenzel, U.O. (2014) Deficiency of the Interleu-kin 17/23 Axis Accelerates Renal Injury in Mice With Deoxycorticosterone Acetate+Angiotensin II-Induced Hypertension. Hypertension. 2014; 63:565-71
  • Deppe, S., Ripperger, A., Weiss, J., Ergün, S., Benndorf, R.A. (2014) Impact of genetic variability in the ABCG2 gene on ABCG2 expression, function, and interaction with AT1 receptor antagonist telmisartan. Biochem Biophys Res Commun. 2014; S0006-291X: 02190-6

PD Dr. Jens Boch

  • Grau, J., Wolf, A., Reschke, M., Bonas, U., Posch, S., and Boch, J. (2013) Computational predictions provide insights into the biology of TAL effector target sites. PLoS Comp. Biol. 9, e1002962.
  • Streubel, J., Richter, A., Reschke, M., and Boch, J. (2013) TALEs - Proteine mit programmierbarer DNA-Bindespezifität. BIOspektrum, in press.
  • Richter, A., Streubel, J., Blücher, C., Szurek, B., Reschke, M., Grau, J., and Boch, J. (2014) A TAL effector repeat architecture for frameshift binding. Nat. Commun. 5, 3447

Dr. Christian R. Eckmann

  • Nousch, M. and Eckmann, C.R. (2015) Translational activation maintains germline tissue homeostasis during adulthood. Worm 4(3), DOI: e1042644
  • Elbaum-Garfinkle, S., Kim, Y., Szczepaniak, K., Chen, C., Eckmann, C.R., Myong, S., and Brangwynne, C.P. (2015) The disordered P granule protein LAF-1 drives phase separation into droplets with tunable viscosity and dynamics. Proc Natl Acad Sci U S A. 2015 Jun 9;112(23):7189-94. doi: 10.1073/pnas.1504822112

Prof. Michael Gekle & Jun-Prof. Claudia Großman

  • Gekle, M., Bretschneider, M., Meinel, S., Ruhs, S., Grossmann, C. (2013)  Rapid mineralocorticoid receptor trafficking. Steroids. 2013 Nov 16.  pii:S0039-128X(13)00240-7
  • Meinel, S., Gekle, M., Grossmann, C. (2014) Mineralocorticoid receptor signaling: Crosstalk with membrane receptors and other modulators. Steroids. 2014 May 28. Volume 91, December 2014
  • Schreier, B., Gekle, M., Grossmann, C. (2014) Role of epidermal growth factor receptor in vascular structure and function. Curr Opin Nephrol Hypertens. 2014 Jan 7. [Epub ahead of print]

Prof. Ingo Heilmann

Dr. Andrea Heinz

  • Heinz, A., Schräder, C.U., Baud, S., Keeley, F.W., Mithieux, S.M., Weiss, A.S., Neubert, R.H.H., Schmelzer, C.E.H. (2014) Molecular-level characterization of elastin-like constructs and human aortic elastin, Matrix Biology, 2014, 38, 12-21
  • Schräder, C.U., Heinz, A., Majovsky, P., Schmelzer, C.E.H. (2015) Fingerprinting Desmosine-Containing Elastin Peptides. J. Am. Soc. Mass. Spectrom., 2015, 26, 762-773

Prof. Stefan Hüttelmaier

  • Köhn, M., Pazaitis, N., Hüttelmaier, S. (2013) Why Y RNAs? About Versatile RNAs and Their Functions. Biomolecules. 2013; 3(1):143-156
  • Wächter, K., Köhn, M., Stöhr, N., Hüttelmaier, S. (2013) Subcellular localization and RNP formation of IGF2BPs (IGF2 mRNA-binding proteins) is modulated by distinct RNA-binding domains. Biol Chem. 2013 Aug;394(8):1077-90
  • Bley, N., Lederer, M., Pfalz, B., Reinke, C., Fuchs, T., Glaß, M.,  Möller, B., Hüttelmaier, S. (2014) Stress granules are dispensable for  mRNA stabilization during cellular stress. NAR, 2014 Dec 8. pii: gku1275
  • Köhn, M., Ihling, C., Sinz, A., Krohn, K., Hüttelmaier, S. (2015) The Y3** ncRNA promotes the 3' end processing of histone mRNAs. Genes Dev 2015 Oct 1;29(19):1998-2003. doi: 10.1101/gad.266486.115.

Prof. Klaus Humbeck

  • Ay, N., Raum, U., Balazadeh, S., Seidensticker, T., Fischer, A., Reuter, G., Humbeck, K. (2014). Regulatory factors of leaf senescence are affected in Arabidopsis plants overexpressing the Histone Methyltransferase SUVH2. J Plant Growth Regul. DOI 10.1007/s00344-013-9384-y

Prof. Ralf Bernd Klösgen

PD Dr. Annette Meister

  • Daum, B., Auerswald, A., Gruber, T., Hause, G., Balbach, J., Kühlbrandt, W., Meister, A. Supramolecular organization of the human N-BAR domain in shaping the sarcolemma membrane; submitted
  • Wölk, C., Janich, C., Pawlowska, D., Drescher, S., Meister, A., Hause, G., Dobner, B., Langner, A., Brezesinski, G. (2015) Lamellar versus micellar structures – aggregation behavior of a triple-chain cationic lipid designed for the non-viral polynucleotide transfer; ChemBioChem 2015, accepted
  • Lechner, B.-D., Ebert, H., Prehm, M., Werner, S., Meister, A., Hause, G., Beerlink, A., Saalwaechter, K., Bacia, K., Tschierske, C., Blume, A. (2015) Temperature dependent in-plane structure formation of an X-shaped bolapolyphile within lipid bilayers; Langmuir 2015, 31, 2839-2850
  • Daum, S., Krüger, D., Meister, A., Auerswald, J., Prinz, S., Briggs, J.A.G., Bacia, K. (2014) Insights from reconstitution reactions of COPII vesicle formation using pure components and low mechanical perturbation; Biol. Chem. 2014, 395, 801-812
  • Meister, A., Finger, S., Hause, G., Blume, A. (2014) Morphological changes of bacterial model membrane vesicles; Eur. J. Lipid Sci. Technol. 2014, 116, 1228-1233
  • Drescher, S., Meister, A., Garamus, V., Hause, G., Garvey, C., Dobner, B., Blume, A. (2014) Phenylene bolaamphiphiles: Influence of the substitution pattern on the aggregation behavior and the miscibility with classical phospholipids; Eur. J. Lipid Sci. Technol. 2014, 116, 1205-1216
  • Schulz, A., Jaksch, S., Schubel, R., Wegener. E., Di, Z., Han, Y., Meister, A., Kressler, J., Kabanov, A. V., Luxenhofer, R., Papadakis, C. M., Jordan, R. (2014) Drug-induced morphology switch in drug delivery systems based on poly(2-oxazoline)s; ACS Nano 2014, 8, 2686-2696
  • Wölk, C., Pawlowska, D., Drescher, S., Auerswald, A., Meister, A., Hause, G., Blume, A., Langner, A., Brezesinski, G., Dobner, B. (2014) New micellar transfection agents; Langmuir 2014, 30, 4905-4915

Prof. Klaus Pillen

  • Nedelkou, I.P., Schubert, A., Léon, J., Pillen, K. Locating exotic QTLs controlling grain quality in the tri-parental exotic spring wheat population SW84 (in preparation)

Prof. Guido Posern

  • Eisenach, P.E., Schikora, F. and Posern, G. (2014): Inhibition of arginyltransferase 1 induces MRTF-A transcriptional activity and promotes directional migration. J. Biol. Chem. 289(51), 35376-35387
  • Kokai, E., Beck, H., Weissbach, J., Anrold, F., Sinske, D., Sebert, U., Gaiselmann, G., Schmidt, V., Walther, P., Münch, J., Posern, G., Knöll, B. (2013): Analysis of nuclear actin by overexpression of wild-type and actin mutant proteins. Histochem. Cell Biology, in press
  • Shaposhnikov, D., Kuffer, C., Storchova, Z., Posern, G. (2013): Myocardin related transcription factors are required for coordinated cell cycle progression. Cell Cycle, 12(11), 1762-72

Prof. Gunter Reuter

  • Rudolph, T., Beuch, S. and Reuter, R. (2013) Lysine-specific histone demethylase LSD1 and the dynamic control of chromatin. Biol. Chem. 394(8): 1019-1028, review article

Prof. Gary Sawers

  • Soboh, B.,  Stripp, S.T., Bielak, C., Lindenstrauß, U., Braussemann, M., Javaid, M., Hallensleben, M., Granich, C., Herzberg, M., Heberle, J. and Sawers, R.G.  
    (2013) The [NiFe]-hydrogenase accessory chaperones HypC and HybG  of Escherichia coli are iron- and carbon dioxide-binding proteins. FEBS  Lett. 587: 2512–2516. doi: 10.1016/j.febslet.2013.06.055
  • Stripp, S.T., B. Soboh, U., Lindenstrauss, M., Braussemann, M., Herzberg, M.,  Nies, D. H., Sawers, R.G., and Heberle, J. (2013) HypD is the scaffold  protein for Fe–(CN)2CO cofactor assembly in [NiFe]–hydrogenase  maturation. Biochemistry 52: 3289–3296. doi: 10.1021/bi400302v
  • Poladyan, A., Trchounian, K., Sawers, R.G., and Trchounian, A. (2013)  Hydrogen-oxidizing hydrogenases 1 and 2 of Escherichia coli regulate the  onset of hydrogen evolution and ATPase activity, respectively, during  glucose fermentation at alkaline pH. FEMS Microbiol. Lett. 348: 143-148.  doi: 10.1111/1574-6968.12281
  • Trchounian, A. and Sawers, R.G. (2014) Novel insights into the  bioenergetics of mixed-acid fermentation: Can hydrogen and proton cycles  combine to help maintain a proton motive force? IUBMB Life 66; 1-7.  doi: 10.1002/iub.1236
  • Pinske, C. and Sawers, R.G. (2014) The importance of iron in the  biosynthesis and assembly of [NiFe]-hydrogenases. Biomolecular Concepts  5; 55-70. doi: 10.1515/bmc-2014-0001
  • Stripp, S.T., Lindenstrauss, U., Granich, Sawers, R.G., Soboh, B. (2014) The Influence of Oxygen on [NiFe]–Hydrogenase Cofactor Biosynthesis and How Ligation of Carbon Monoxide Precedes Cyanation. September 11, 2014 DOI: 10.   1371/journal.   pone.   0107488   
  • Sawers, R.G. (2015) Of mothballs and old yellow enzymes. Molecular Microbiology 95(2), 157–161. doi:10.   1111/mmi.   12874   
  • Hartwig, S., Thomas, C., Krumova, N., Quitzke, V., Türkowsky, D., Jehmlich, N., Adrian, L.  and Sawers, R.G. (2015) Heterologous complementation studies in Escherichia coli with the Hyp accessory protein machinery from Chloroflexi provide insight into [NiFe]-hydrogenase large subunit recognition by the HypC protein family. Microbiology, 161, 2204–2219. doi: 10.1099/mic.0.000177

Dr. Martin Schattat

  • Mathur, J., Barton, K.A., Schattat, M.H. (2013) Fluorescent Protein Flow within Stromules. The Plant Cell 25: 2771–2772 letter to the editor
  • Erickson, J.L., Ziegler, J., Guevara, D., Abel, S., Klösgen, R.B., Mathur, J.,  Rothstein, S.J., Schattat, M.H. (2014) Agrobacterium-derived cytokinin  influences plastid morphology and starch accumulation in Nicotiana  benthamiana during transient assays. BMC Plant Biol 14: 127 research article
  • Schattat, M.H., Barton, K.A., Mathur, J. (2014) The myth of interconnected  plastids and related phenomena. Protoplasma. doi:  10.1007/s00709-014-0666-4 new ideas in cell biology   
  • Ziegler, J., Qwegwer, J., Schubert, M., Erickson, J.L., Schattat, M.H., Bürstenbinder, K., Grubb, C.D., Abel, S. (2014) Simultaneous analysis of apolar phytohormones and 1-aminocyclopropan-1-carboxylic acid by high performance liquid chromatography/electrospray negative ion tandem mass spectrometry via 9-fluorenylmethoxycarbonyl chloride derivatization. Journal of Chromatography A. Journal of Chromatography A, 1362: 102–109
  • Franke, L., Storbeck, B., Erickson, J.L., Rödel, D., Schröter, D., Möller, B., Schattat, H.M. (2015) The 'MTB Cell Counter' a versatile tool for the semi-automated quantification of sub-cellular phenotypes in fluorescence microscopy images. A case study on plastids, nuclei and peroxisomes. Journal of Endocytobiosis and Cell Research :25-36 (Accepted 18 April 2015)

Prof. Elisabeth Schwarz

  • Thieme, T., Patzschke, R., Job, F., Liebold, J., Seemann, P., Lilie, H., Balbach, J., Schwarz, E. (2014) Biophysical and structural characterization of a folded core domain within the proregion of growth and differentiation factor-5. The FEBS journal 281:4866-4877. PMID: 25174448

Prof. Daniel Sebastiani

  • Pylaeva, S., Allolio, C., Koeppe, B., Denisov, G. S., Limbach, H.-H., Sebastiani, D. and Tolstoy, P. M. (2015) Proton transfer in a short hydrogen bond caused by solvation shell fluctuations: an ab initio MD and NMR/UV study of an (OHO)− bonded system. Phys. Chem. Chem. Phys., 2015, 17, 4634- 4644
  • Bekcioglu, G., Allolio, C., Sebastiani, D. (2015) Nanoscale Water Wires in Aqueous Solutions: Fiction or Characteristic Structural Motfis? J. Phys. Chem. B, 2015, 119 (10), 4053–4060

Prof. Andrea Sinz

  • Doberenz, C., Zorn, M. et al. (2014) Pyruvate Formate-Lyase Interacts Directly with the Formate Channel FocA to Regulate Formate Translocation. J. Mol. Biol. 426, 2827-2839

Prof. Wolfgang Sippl & Dr. Matthias Schmidt

  • Wichapong, K., Rohe, A., Platzer, C., Slynko, I., Erdmann, F., Schmidt, M., Sippl, W. (2014) Application of Docking and QM/MM-GBSA Rescoring to Identify Novel Myt1 Kinase Inhibitors. J. Chem. Inf. Mod. 2014, 54, 881-893
  • Slynko, I., Scharfe, M., Rumpf, T., Jung, M., Sippl,W. (2014) Combined approach for PRK1 virtual screening: from ensemble docking to rescoring using MMPB(GB)SA binding free energy calculation and QSAR model development. J. Chem. Inf. Model. 2014, 54, 138−150
  • Rohe, A., Henze, C., Erdmann, F., Sippl, W., Schmidt, M. (2013) A Fluorescence Anisotropy–Based Myt1 KinaseBinding Assay. Assay and Drug Development Technologies, 2013 Nov 14. [Epub ahead of print], DOI: 10.1089/adt.2013.534
  • Rohe, A., Göllner, C., Wichapong, K., Erdmann, F., Al-Mazaideh, G., Sippl, W., Schmidt, M. (2013) Evaluation of potential Myt1 kinase inhibitors by TR-FRET based binding assay. European Journal of Medicinal Chemistry 61, 41-48
  • Rohe, A., Göllner, C., Erdmann, F., Sippl, W., Schmidt, M. (2014) The glycoglycerolipid 1,2-Dipalmitoyl-3-(N-palmitoyl-6'-amino-6'-deoxy-α-D-glucosyl)-sn-glycerol is no inhibitor of the human Myt1 kinase. J. Enz. Inh. Med. Chem. (2015), 30, 514-517
  • Rohe, A., Platzer, C., Masch, A., Greiner, S., Henze, C., Ihling, C., Erdmann, F., Schutkowski, M., Sippl, W., Schmidt, M. (2015) Identification of peptidic substrates for the human kinase Myt1 using peptide microarrays. Bioorganic & Medicinal Chemistry (2015), 23, 4936-4942

Prof. Milton T. Stubbs

  • Stelter, M., Fandrich, U., Franzke, K., Schierhorn, A., Breithaupt, C., Parthier, C. and Stubbs, M.T. (2013) High level expression of the Drosophila Toll receptor ectodomain and crystallization of its complex with the morphogen Spätzle. Biol Chem. 394, 1091-1096
  • Ursel, C., Fandrich, U., Hoffmann, A., Sieg, T., Ihling, C. and Stubbs, M.T. (2013) In-vitro maturation of Drosophila melanogaster Spätzle protein with refolded Easter reveals a novel cleavage site within the prodomain. Biol Chem. 394, 1069-1075
  • Parthier, C., Stelter, M., Ursel, C., Fandrich, U., Lilie, H., Breithaupt, C. and Stubbs, M.T. (2014) Structure of the Toll-Spätzle complex, a molecular hub in Drosophila development and innate immunity. PNAS 111, 6281-6286

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